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DeCS
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Descriptor English:
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Substrate Cycling
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Descriptor Spanish:
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Ciclo del Sustrato
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Descriptor Portuguese:
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Ciclização de Substratos
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Synonyms English:
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Futile Cycling
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Tree Number:
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G02.111.087.820
G02.149.115.820
G03.495.335.835
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Definition English:
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A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise. |
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Indexing Annotation English:
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restricted to enzyme activity; almost never IM; coord NIM with specific enzyme (IM)
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History Note English:
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89
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Allowable Qualifiers English:
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Record Number:
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23842
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Unique Identifier:
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D015219
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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